Faculty of Medicine, Dentistry and Health Sciences Department of Surgery Austin Health

Research Publications 2003 –

Listed in this section are all the research articles that have been published by the various members of the Department of Surgery, Austin Health since the year 2003. The high volume of publications in peer reviewed journals support the quality of basic science and clinical research undertaken in this department. The University of Melbourne research report lists all research publications and projects from the University. For a searchable database of publications data, please see the Research Publications Database. The University of Melbourne Research Reports are available from the MRO Research Data Collection & Performance Statistics Website.

Cancer Biology Research Group

top of page
  1. Hollande, F., Lee, D.J., Choquet, A., Roche S. and BALDWIN, G.S. (2003) Adherens and tight junctions are regulated via different pathways by progastrin in epithelial cells. J. Cell Science. 116: 1187-1197.
  2. Pannequin, J., Kovac, S., Tantiongco, J.-P., Norton, R.S., Shulkes, A. Barnham, K. and BALDWIN, G.S. (2004) A novel effect of bismuth ions: Selective inhibition of the biological activity of glycine-extended gastrin. J. Biol. Chem. 279: 2453-2460.
  3. BALDWIN, G.S. (2004) Properties of the complex between recombinant human progastrin and ferric ions. The Protein Journal. 23: 65-70.
  4. Pannequin, J., Tantiongco, J.-P., Kovac, S., Shulkes, A. and BALDWIN, G.S. (2004) Divergent roles for ferric ions in the bioactivity of amidated and non-amidated gastrins: Ferric ions are not essential for the CCK-2 receptor-mediated bioactivity of amidated gastrins. J. Endo. 181: 315-325.
  5. Lachal, S., Ford, J., Shulkes, A. and BALDWIN, G.S. (2004) PPARa agonists stimulate progastrin production in human colorectal carcinoma cells. Regulatory Peptides. 120: 243-251.
  6. Dumesny, C., Whitley, J.C., BALDWIN, G.S., Giraud, A.S. and Shulkes, A. (2004) Developmental expression and biological activity of gastrin-releasing peptide (GRP) and GRP receptors in the kidney. Am. J. Physiol. Renal Physiology. 287: F578-585.
  7. He, H., Shehan, B.P., Barnham, K.J., Norton, R.S., Shulkes, A. and BALDWIN, G.S. (2004) Biological activity and ferric ion binding of fragments of glycine-extended gastrin. Biochemistry. 43: 11853-11861.
  8. Paterson, A.C., Lockhart, S.M., Baker, J., Neumann, G., BALDWIN, G.S. and Shulkes, A. (2004) Identity and regulation of stored and secreted progastrin-derived peptides in sheep. Endocrinology. 145: 5129-5140.
  9. Patel, O., Dumesny, C., Giraud, A.S., BALDWIN, G.S. and Shulkes, A. (2004) Amidated and glycine-extended gastrin-releasing peptide stimulate proliferation and migration of a colorectal cancer cell line via the same receptor. Biochem. Pharmacol. 68: 2129-2142.
  10. BALDWIN, G.S. (2004) Gastrins, gastrin receptors and colon cancer. In: Gastrin in the New Millenium (Merchant, J.L. ed.). pp 311-318. CURE Foundation, Los Angeles.
  11. Aly, A., Shulkes, A. and BALDWIN, G.S. (2004) Gastrins, cholecystokinins and gastrointestinal cancer. Biochim. Biophys. Acta Reviews on Cancer. 1704: 1-10.
  12. He, H., Pannequin, J., Tantiongco, J.-P., Shulkes A. and BALDWIN, G.S. (2005) Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway. Am. J. Physiol. Gastrointestinal and Liver Physiology.  289: G478-G488.
  13. Hollande, F., Shulkes, A. and BALDWIN, G.S. (2005) Signalling junctions in the gut epithelium. Sci STKE. 2005: pe 13.
  14. Dumesny, C., Patel, O., Giraud, A.S., BALDWIN, G.S. and Shulkes, A. (2006) Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP). Endocrinology. 147: 502-509.
  15. Houli, N., Giraud, A.S., BALDWIN, G.S. and Shulkes, A. (2006) Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo. Regulatory Peptides. 134: 9-16.
  16. Smith, K., Patel, O., Lachal, S., Jennings, I., Kemp, B., Burgess, J., BALDWIN, G.S. and Shulkes, A. (2006) Production, secretion and biological activity of the C-terminal flanking peptide of human progastrin. Gastroenterology. 131: 1463-1474.
  17. Smith, K., Kovac, S., Anderson, G.J., Shulkes, A. and BALDWIN, G.S. (2006) Circulating gastrin is increased in hemochromatosis. F.E.B.S. Letters. 580: 6195-6198.
  18. Shulkes, A., Giraud, A.S. and BALDWIN, G.S. (2006) Regulation of gastric acid secretion. In: Physiology of the Gastrointestinal Tract (Johnson, L.R., Barrett, K.E., Ghishan, F.K., Merchant, J.L., Said, H.M., Wood, J.D., eds.). 4th edition, pp 1223-1258. Elsevier, San Diego.
  19. Patel, O., Shulkes, A. and BALDWIN, G.S. (2006) Gastrin-releasing peptide and cancer. Biochim. Biophys. Acta Reviews on Cancer. 1766: 23-41.
  20. Patel, O., Dumesny, C., Shulkes, A. and BALDWIN, G.S. (2007) C-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor. Endocrinology. 148: 1330-1339.
  21. Patel, O., Dumesny, C., Shulkes, A. and BALDWIN, G.S. (2007) Recombinant bioactive fragments from the gastrin-releasing peptide precursor C-terminus. Cancer Letters.  254: 87-93.
  22. BALDWIN, G.S., Patel, O. and Shulkes, A. (2007) Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors. Regulatory Peptides. 143: 1-14.
  23. Pannequin, J., Delaunay, N., Buchert, M., Surrel, F., Bourgaux, J.-F., Ryan, J., Boireau, S., Coelho, J., Pélegrin, A., Singh, P., Shulkes, A., Yim, M.,  BALDWIN, G.S., Pignodel, C., Lambeau, J., Jay, P., Joubert, D. and Hollande, F., (2007) b–Catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors. Gastroenterology. 133: 1554-1568.
  24. BALDWIN, G.S. and Shulkes, A. (2007) CCK receptors and cancer. Current Topics in Medicinal Chemistry. 7: 1232-6.
  25. Patel, O., Shulkes, A. and BALDWIN, G.S. (2007) Gastrin-releasing peptide. In: Cancer Encyclopedia. (Schwab, M., ed.). 2nd edition, Springer, Berlin.
  26. He, H., Yim, M., Liu, K.H., Cody, S.C., Shulkes, A. and BALDWIN, G.S. (2008) Involvement of G proteins of the Rho family in the regulation of bcl-2-like protein expression and caspase 3 activation by gastrins. Cellular Signalling. 20: 83-93.
  27. Dizdarevic, A., Harun, N., Malcontenti-Wilson, C., Shulkes, A., Christophi C. and BALDWIN, G.S. (2008) Gastrin is not required for liver regeneration. A. N. Z. J. Surgery. 78: 1-4.
  28. Friedrich, S., Sims, Y. and BALDWIN, G.S. (2008) Preparation and properties of recombinant rat and human procholecystokinin57-95. The Protein Journal. 27: 186-191.
  29. He, H., Shulkes, A. and BALDWIN, G.S. (2008) PAK1 interacts with b-catenin and is required for the regulation of the b-catenin signalling pathway by gastrins. Biochim. Biophys. Acta. Molecular Cell Research. 1783: 1943-1954.
  30. BALDWIN, G.S., Bailey, M.F., Shehan, B.P., Sims, I. and Norton, R.S. (2008) Tyrosine modification enhances ferric ion binding. Biochem. J. 416: 77-84.
  31. Kovac, S., Smith, K., Anderson, G.J., Burgess, J.R., Shulkes, A. and BALDWIN, G.S. (2008) Interrelationships between circulating gastrin and iron status in mice and humans. Am. J. Physiol. Gastrointestinal and Liver Physiology.  295: G855-G861.
  32. He, H. and BALDWIN, G.S. (2008) Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins. Int. J. Biochem. Cell Biol. 40: 2018-2022.
  33. BALDWIN, G.S. (2009) Phosphorylation of neighbouring residues incyclin-dependent kinase 2 (CDK2) peptides creates additional calcium and ferric ion binding sites. Biochem. Biophys. Res. Commun. 379: 151-154.
  34. Ferrand, A., Sandrin, M.S., Shulkes, A. and BALDWIN, G.S. (2009) Expression of gastrin precursors by CD133-positive colon cancer stem cells is crucial for tumour growth. Biochim. Biophys. Acta. Molecular Cell Research. 1793: 477-488.
  35. Kovac, S., Shulkes A. and BALDWIN, G.S. (2009) Peptide processing and biology in human disease. Curr. Opin. Endocrinol. Diabetes Obes. 16: 79-85.
  36. Ischia, J.J., Patel, O., Shulkes A. and BALDWIN, G.S. (2009) Gastrin-releasing peptide: Different forms, different functions. BioFactors. 35: 69-75.

HPB Research Group

top of page
  1. Christophi C. Nikfarjam M. Muralidharan V. Dudley F. “Primary bile duct carcinoma in histocompatibility antigen-identical twins.” Journal of Gastroenterology & Hepatology. 18(4):469-72, 2003.
  2. Muralidharan V, Nikfarjam M, Malcontenti-Wilson C, Christophi C. “Interstitial laser hyperthermia and the biological characteristics of tumor: study in a murine model of colorectal liver metastases.” Journal of Clinical Laser Medicine & Surgery. 21(2):75-83, 2003.
  3. Nikfarjam M, Muralidahran V, Malcontenti-Wilson C, Christophi C. “Scanning Electron Microscopy Study of the Blood Supply of Human Colorectal Liver Metastases.” European Journal of Surgical Oncology, 29(10), 856-861, 2003. 
  4. Nikfarjam m, Evans P, Christophi C. “Pancreatic Resection for Melanoma” HPB, 5(3), 174-179, 2003.
  5. M Nikfarjam, C Christophi. "Interstitial Laser Thermotherapy for Liver Tumours" British Journal of Surgery, 90:1033-1047, 2003.
  6. Lontos S, Jones RM, Angus PW, Gow PJ. “Acute liver failure associated with the use of herbal preparations containing black cohosh.” Med J Aust. 2003 Oct 6;179(7):390-1
  7. Nikfarjam M, Evans P, Muralidharan V, Christophi C. “Primary Hepatic Carcinoid Tumours - Review.” HPB, 6(1); 13-17, 2004.
  8. Nikfarjam M, Evans P, Muralidharan V, Christophi C “Not all hepatic carcinoids are metastases” Journal of Gastroenterology and Hepatology, (Letter) 19(2): 232-233, 2004.
  9. Muralidharan V, Nikfarjam M, Malcontenti-Wilson C, Christophi C. “The effect of interstitial laser hyperthermia in a murine model of colorectal liver metastases – A scanning electron microscopic study” World Journal of Surgery, 28(1): 33-37, 2004.
  10. Christophi C, Nikfarjam M, Muralidharan V, Malcontenti-Wilson C “Long-Term Survival of Patients with Unresectable Colorectal Liver Metastases treated by Percutaneous Interstitial Laser Thermotherapy” World Journal of Surgery, 28(10):987-94, 2004.  
  11. Gow PJ, Jones RM, Dobson JL, Angus PW. “Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit.” J Gastroenterol Hepatol. 2004 Feb;19(2):154-9.
  12. Rerksuppaphol S, Hardikar W, Smith AL, Wilkinson JL, Goh TH, Angus P, Jones R. “Successful stenting for Budd-Chiari syndrome after pediatric liver transplantation: a case series and review of the literature.” Pediatr Surg Int. 2004 Feb;20(2):87-90. Epub 2004 Feb 10
  13. Naka T, Wan LI, Bellomo, R, Zong Wang B, Jones R, Berry R, Angus P, Gow P. “Kidney failure associated with liver transplantation or liver failure:  The impact of continuous veno-venous hemofiltraton.”  The Intern Journ of Artificial Organs / Vol. 27 / no 11, 2004
  14. Nikfarjam M, Malcontenti-Wilson C, Fanartzis M, Daruwalla J, Christophi C. “A model of partial hepatectomy in mice.” Journal of Investigative Surgery, 17:291-294, 2004.
  15. Katz D. Nikfarjam M. Sfakiotaki A. Christophi C. “Selective endoscopic cholangiography for the detection of common bile duct stones in patients with cholelithiasis.” Endoscopy, 36(12):1045-9, 2004.
  16. Nikfarjam M, Malcontenti-Wilson C, Christophi C. “Focal hyperthermia produces progressive tumor necrosis independent of the initial thermal effects.” Journal of Gastroenterology and Hepatology, 9(3):410-7, 2005
  17. Mehrdad Nikfarjam M.B.B.S, Vijayargavan Muralidharan, PhD, Caterina Malcontenti-Wilson B.Sc., Jurstine Daruwalla B.Sc., Kim Su, B.Sc., Christopher Christophi M.D. “The Apoptotic Response of Liver and Colorectal Liver Metastases to Focal Hyperthermic Injury ” Anti Cancer Research, 25 (2B): 1413-1419, 2005.
  18. Michael A. Fink, Peter W. Angus, Paul J. Gow, S. Roger Berry, Bao Z. Wang, Vijayaragavan Muralidharan, Christopher Christophi, Robert M Jones. “Liver transplant recipient selection – MELD versus clinical acumen” Liver Transpl, 11(6): 621-6, 2005.
  19. Mehrdad Nikfarjam M.B.B.S, Vijayaragavan Muralidharan, Caterina Malcontenti-Wilson B.Sc., Jurstine Darawalla B.Sc., Wendy McLaren, Christopher Christophi M.D.  “Progressive microvascular injury in normal liver and colorectal liver metastases following focal hyperthermia therapy.” Lasers Surg Med, 37(1): 64-73, 2005.
  20. Mehrdad Nikfarjam, Vigayaragavan Muralidharan, Caterina Malcontenti-Wilson, Christopher Christophi “Heat Shock protein and Kupffer cell response to focal hyperthermia in normal liver and colorectal liver metastases.” Int J Hyperthermia,  21(4): 319-32. 2005.
  21. Jurstine Daruwalla, Mehrdad Nikfarjam, Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Michael Fanartzis & Chris Christophi. “The effect of Thalidomide on Colorectal Cancer Liver Metastases in CBA mice.” J Surg Oncol, 1;91(2): 134-40, 2005.
  22. Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Christopher Christophi  “Mechanisms of focal heat destruction of liver tumours.” J Surg Res.127(2):208-23, 2005.
  23. Mehrdad Nikfarjam M.B.B.S,  Caterina Malcontenti-Wilson B.Sc., Christopher Christophi M.D. “A Comparison of 980 nm and 1064 nm wavelengths lasers for interstitial laser thermotherapy of the liver”  Photomedicine and Laser Surgery, 23(3):284-8, 2005.
  24. Cherk M, Nikfarjam M, Christophi C. “Retroperitoneal lymphangioma.” Asian Journal of  Surgery, 29(1):51-4, 2006
  25. Mehrdad Nikfarjam, Vigayaragavan Muralidharan, Caterina Malcontenti-Wilson, Christopher Christophi “Altered growth patterns of colorectal liver metastases following focal hyperthermia ablation.” Surgery, 139(1):73-81, 2006.
  26. M Nikfarjam, V Muralidharan, C Malcontenti-Wilson, J Daruwalla, W Mclaren, and C Christophi. “Impact of blood flow occlusion on liver necrosis following focal hyperthermia” ANZ Journal of Surgery, 76(1-2):84-91 2006.
  27. Dobson, JL, Angus PW, Jones R, Crowley P, Gow PJ. “Flucloxacillin-induced aplastic anaemia and liver failure.” Transpl Intern 18:487-9, 2005.
  28. Hong MKh, Angus PW, Jones RM, Vaughan RB, Gow PJ. “Predictors of improvement in renal function after calcineurin inhibitor withdrawal for post-liver transplant renal dysfunction.” Clin Transplant. 19(2):193-8, 2005.
  29. Scott AM, Lee FT, Jones R, Hopkins W, MacGregor D, Cebon JS, Hannah A, Chong G, U P, Papenfuss A, Rigopoulos A, Sturrock S, Murphy R, Wirth V, Murone C, Smyth FE, Knight S, Welt S, Ritter G, Richards E, Nice EC, Burgess AW, Old LJ. “A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake.” Clin Cancer Res. 11(13):4810-7, 2005.
  30. Lodge JP, Jonas S, Jones RM, Olausson M, Mir-Pallardo J, Soefelt S, Garcia-Valdecasas JC, McAlister V, Mirza DF; rFVIIa OLT Study Group. “Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation.” Liver Transpl. 2005 Aug;11(8):973-9.
  31. Fink MA, Jones RM. “The use of a composite graft of iliac artery and inferior mesenteric vein in liver transplantation.” Transplantation International, 19: 81-83, 2006.
  32. Su K, Christophi C. “Experimental Animal Models of Acute Pancreatitis.” HPB, 8(4): 264 - 286, August 2006.
  33. Cuthbertson C, Christophi C. “The Potential Effects of Hyperbaric Oxygen Therpay in Acute Pancreatitis.” ANZ Journal of Surgery, 76(7):625-630, July 2006.
  34. Cuthbertson C, Christophi C. “Disturbances of the Microcirculation in Acute Pancreatitis.” British Journal of Surgery, 93(5):518-530, May 2006.
  35. Daruwalla J, Christophi C. “The Treatment of Malignancy by hyperbaric Oxygen Therapy: A review ” World Journal of Surgery, 30(12):2112-31, December 2006.
  36. Daruwalla J, Christophi C. “Disturbances of the Microcirculation in Acute Pancreatitis.” European Journal of Cancer, 42(18):3304-11, December 2006.
  37. Michael A. Fink, S. Roger Berry, Paul J. Gow , Peter W. Angus,  Bao Z. Wang, Vijayaragavan Muralidharan, Christopher Christophi, Robert M Jones. “Risk Factors for Liver Transplantation Waiting List Mortality.” J Gastroenterol Hepatol.22(1):119-24, January 2007.

Transplantation Immunobiology Research Group

top of page
  1. Trapani, J.A., V.R. Sutton, K.Y. Thia, Y.Q. Li, C.J. Froelich, D.A. Jans, M.S. Sandrin and K.A. Browne.  A clathrin/dynamin- and mannose-6-phosphate receptor independent pathway for granzyme B-induced cell death.  J. Cell Biol. 160: 223-233 (2003).
  2. Sykes, M., A. d’Apice and M.S. Sandrin.  Position paper of the ethics committee of the international xenotransplantation association.  Xenotransplantation 10:194-204 (2003).
  3. Taylor, S.G., I.F.C. McKenzie and M.S. Sandrin.  Characterization of the rat á(1,3)Galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galá(1,3)Gal by two separate glycosylation pathways.  Glycobiology 13:327-337 (2003).
  4. Ramsland, P.A., W. Farrugia, E. Yuriev, A.B. Edmundson and M.S. Sandrin.  Evidence for structurally conserved recognition of the major carbohydrate xenoantigen by natural antibodies.   Cellular and Molecular Biology 49:307-317(2003).
  5. McKenzie, I.F.C., Y.Q. Li, P-X. Xing, I. Dinatale, M. Koulmanda, B.E. Loveland and M.S. Sandrin.  CD46 protects pig islets from antibody but not cell – mediated destruction in the mouse.  Xenotransplantation. 10:615-621 (2003).
  6. Webster, N.L., M. Forni, M.L. Bacci, R. Giovannoni, R. Razzini, P. Fantinati, A. Zannoni, L. Fusetti, L. Dalprà, M. Bianco, M. Papa, E. Seren, M.S. Sandrin, I.F.C. McKenzie and M. Lavitrano. Multi-transgenic pigs expressing three fluorescent proteins produced with high efficiency by sperm mediated gene transfer. Molecular Reproduction and Development 72:68-76 (2005)
  7. Webster, N.L., J. Wee, S.J. Uren, W. Boyle and M.S. Sandrin.  Production and purification of human Indoleamine 2,3-Dioxygenase (IDO) protein in the Baculovirus expression system and production and characterization of egg yolk antibody against the purified HuIDO.  Immunology & Cell Biology 83:542-548 (2005)
  8. Milland, J., D. Christiansen and M.S. Sandrin.  Alpha1,3-galactosyltransferase knockout pigs are available for xenotransplantation: are glycosyltransferases still relevant?  Immunology & Cell Biology 83:687-693 (2005)
  9. Milland, J., D. Christiansen, B.D. Lazarus, S.G. Taylor and M.S. Sandrin.  The molecular basis for Gal α(1,3)Gal expression in animals with a deletion of the α(1,3) galactosyltransferase gene.  J. Immunology 176:2448-2454 (2006)
  10. Mulley, W.R., J.L. Wee, D. Christiansen, J. Milland, F.L. Ierino and M.S. Sandrin.  Lentiviral expression of CTLA4Ig inhibits primed xenogeneic lymphocyte proliferation and cytokine responses.  Xenotransplantation 13:248-252 (2006).
  11. Christiansen, D., E. Mouhtouris, J. Milland, A. Zingoni, A. Santoni and M.S. Sandrin.  Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161).  Xenotransplantation 13:440-446, (2006).
  12. Weilin, S. and M.S. Sandrin.  Some ethical problems in xenotransplantation: Introductory remarks at ethics workshop.  Xenotransplantation 13:500-501, (2006)
  13. Layton, D.S., A.D.G. Strom, T.E. O’Neil, M.M. Broadway, G.L. Stephenson, K.R. Morris, M. Muralitharan, M.S. Sandrin, F.L. Ierino and A.G.D. Bean. Development of an anti-porcine CD34 monoclonal antibody that identifies hematopoietic stem cells.  Experimental Hematology 35:171-178, (2007).
  14. Milland, J and M.S. Sandrin. ABO blood group and related antigens, natural antibodies and transplantation.  Tissue Antigens 68:459–466, (2006).
  15. Fullmer, J.M., M. Riedl, F.G. Williams, M. Sandrin and R. Elde.  Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. J Comp Neurol 501:70-82, (2007).

Regulatory Peptide Research Group

top of page
  1. Hollande F, Lee D J, Choquet A, Roche S, Baldwin G S. Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells.  Journal of Cell Science, 2003; 116: 1187-1197.
  2. Aly, A., Shulkes, A. and BALDWIN, G.S. Gastrins, cholecystokinins and gastrointestinal cancer. Biochim. Biophys. Acta Reviews on Cancer. 2004; 1704: 1-10.
  3. Shulkes A. Neurotensin.  Encyclopedia of Gastroenterology, 2004, 726-730.
  4. Dumesny C, Whitley J C, Baldwin G S, Giraud A S, Shulkes A.  Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney.  Am J Physiology – Renal Physiology, 2004, 287:  F578-F585.
  5. Judd L M, Alderman B M, Howlett M, Shulkes A, Dow C, Moverley J, Grail D, Jenkins B J, Ernst M, Giraud A S.  Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.  Gastroenterology, 2004, 126: 196-207.
  6. Patel O, Dumesny C, Giraud A S, Baldwin G S, Shulkes A.  Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor.  Biochemical Pharmacology, 2004, 68: 2129-2142.
  7. Paterson AC, Lockhart S M, Baker J, Neumann G, Baldwin G S, Shulkes A.  Identity and regulation of stored and secreted progastrin-derived peptides in sheep.  Endocrinology, 2004, 145: (11) 5129-5140.
  8. Pannequin J, Kovac S, Tantiongco J-P, Norton R S, Shulkes A, Barnham K J, Baldwin G S.  A novel effect of bismuth ions.  J Biological Chemistry, 2004, 279: (4) 2453-2460.
  9. Baldwin G S.  Properties of the complex between recombinant human progastrin and ferric ions.  The Protein Journal, 2004, 23: (1) 65-70.
  10. Lachal S, Ford J, Shulkes A, Baldwin G S.  PPARα agonists stimulate progastrin production inhuman colorectal carcinoma cells.  Regulatory Peptides, 2004, 120: 243-251.
  11. Pannequin J, Tantiongco J-P, Kovac S, Shulkes A, Baldwin G S.  Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins.  J Endocrinology, 2004, 181: 315-325.
  12. He H, Shehan P, Barnham K J, Norton R S, Shulkes A, Baldwin G S.  Biological activity and ferric ion binding of fragments of glycine-extended gastrin.  Biochemistry, 2004, 43 (37) 11853-11861.
  13. Kolivas S, Shulkes A.  Regulation of expression of the receptors controlling gastric acidity.  Regulatory Peptides, 2004; 121: 1-9.
  14. Aly A, Shulkes A, Baldwin G S.  Gastrins, cholecystokinins and gastrointestinal cancer.  Biochimica et Biophysica Acta, 2004; 1704: 1-10
  15. He, H., Pannequin, J., Tantiongco, J.-P., Shulkes A. and BALDWIN, G.S. Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway. Am. J. Physiol. 2005; 289: G478-G488.
  16. Weiland T J, Kent S, Voudouris N J, Shulkes A.  The effect of lipopolysaccharide on cholecystokinin in murine plasma and tissue.  Peptides, 2005, 26: 447-455.
  17. Patel, O., Shulkes, A. and BALDWIN, G.S. Gastrin-releasing peptide and cancer. Biochim. Biophys. Acta Reviews on Cancer. 2006; 1766: 23-41.
  18. Smith, K., Patel, O., Jennings, I., Kemp, B., Burgess, J., Anderson, G., BALDWIN, G.S. and Shulkes, A. Production, secretion and biological activity of the C-terminal flanking peptide of human progastrin. Gastroenterology. 2006; 131:1463-1474.
  19. Smith, K., Kovac, S., Anderson, G.J., Shulkes, A. and BALDWIN, G.S. 2006 Circulating gastrin is increased in hemochromatosis. F.E.B.S. Letters. 2006; 580:6195-6198.
  20. Patel, O., Dumesny, C., Shulkes, A. and BALDWIN, G.S. C-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor. Endocrinology. In press, 11.11.2006.
top of page